| 摘要 |
PCT No. PCT/EP94/00881 Sec. 371 Date Sep. 29, 1995 Sec. 102(e) Date Sep. 29, 1995 PCT Filed Mar. 21, 1994 PCT Pub. No. WO94/22303 PCT Pub. Date Oct. 13, 1994One object of the invention, therefore, is to provide encapsulated biologically active solid microparticle agglomerates, each agglomerate comprising either I i) at least two closely associated microparticles, each microparticle being coated partially or completely by at least one discrete layer of a polymer, and ii) at least one outer discrete coating layer of the same polymer which envelops the coated microparticles to form an agglomerate of closely associated microparticles, or II i) a cluster of at least two closely associated microparticles, each microparticle being coated partially or completely by at least one layer of a polymer, the microparticles adhering together through the polymer to form said cluster, and ii) at least one outer discrete coating layer of the same polymer which envelops said cluster to form a discrete agglomerate, wherein in types I and II an inter-phase boundary is formed between each particle and the first coating layer, between individual coating layers and between the outer agglomerating envelope layer and the penultimate coating layer, and the total weight of polymer coating within and outside the agglomerate is no greater than 40% of the average agglomerate weight. |
