RADIOPHARMACEUTICAL FORMULATIONS HAVING NON-STANNOUS REDUCTANTS

摘要

The present invention relates to novel radiopharmaceutical imaging agents having non-stannous reductants. Metallic compounds, such as Cu(I), Cu(II), Co(II), Fe(II), Sn(O), Zr(O), Cr(II) and Zn(O), will act to effectively reduce radionuclide containing solutions. Several nonmetallic compounds, such as acids in general, dithionite, formamidine, formamadine sulfinic acid, phosphite, hypophosphite, dithiotreitol, hydrochloric acid, and borohydric acid may also be used to reduce radionuclide containing solutions. Moreover, it has been discovered that several agents, such as phosphines, sulfhydryl compounds, phosphites, thiols, thioethers, borates, borocyano groups, ascorbates and gentisates efficiently reduce radionuclide containing solutions and complex with the radionuclide at the same time. The present invention also relates to kits for forming radiopharmaceutical imaging agents, such kits including non-stannous reducing agents.