发明名称 |
HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS |
摘要 |
A compound of the general formula (I): (M1)n-Q-(M2)1-n-L-A wherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group; and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
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申请公布号 |
CA2155307(A1) |
申请公布日期 |
1994.10.13 |
申请号 |
CA19942155307 |
申请日期 |
1994.03.28 |
申请人 |
ZENECA LIMITED |
发明人 |
WAYNE, MICHAEL GARTH;SMITHERS, MICHAEL JAMES;RAYNER, JOHN WALL;FAULL, ALAN WELLINGTON;PEARCE, ROBERT JAMES;BREWSTER, ANDREW GEORGE;SHUTE, RICHARD EDEN;MILLS, STUART DENNETT;CAULKETT, PETER WILLIAM RODNEY |
分类号 |
A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4427;A61K31/445;A61K31/4545;A61K31/47;A61K31/505;A61K31/5377;A61P7/02;A61P43/00;C07D213/74;C07D213/81;C07D215/14;C07D215/42;C07D239/42;C07D401/04;C07D401/12;C07D401/14;C07D405/12;C07D521/00;(IPC1-7):C07K5/075;C07D473/00;C07D471/04;A61K38/05;C07D491/052;A61K38/06;C07K5/093;A61K31/495;A61K31/535;A61K31/55 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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