发明名称 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS
摘要 TITLE OF THE INVENTION HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS Compounds of formula <IMG> where R1 and R2 are independently hydrogen or optionally-substituted C1-4alkyl or aryl, or R1 and R2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
申请公布号 CA2120192(A1) 申请公布日期 1994.10.01
申请号 CA19942120192 申请日期 1994.03.29
申请人 MERCK & CO., INC. 发明人 VACCA, JOSEPH P.;GUARE, JAMES P.;DORSEY, BRUCE D.;HOLLOWAY, M. KATHARINE;HUNGATE, RANDALL W.
分类号 C07D241/04;A61K9/70;A61K31/40;A61K31/401;A61K31/4025;A61K31/4427;A61K31/443;A61K31/4433;A61K31/445;A61K31/495;A61K31/496;A61K31/70;A61K31/7068;A61K31/7072;A61K45/06;A61P31/12;A61P31/18;C07D207/16;C07D211/60;C07D401/06;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D417/12;(IPC1-7):A61K31/70 主分类号 C07D241/04
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