| 发明名称 |
PHENOXYPHENYLACETIC ACID DERIVATIVES |
| 摘要 |
TITLE OF THE INVENTION PHENOXYPHENYLACETIC ACID DERIVATIVES Phenoxyphenylacetic acids and derivatives of the general structural formula I <IMG> I have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
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| 申请公布号 |
CA2119051(A1) |
申请公布日期 |
1994.09.20 |
| 申请号 |
CA19942119051 |
申请日期 |
1994.03.15 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
BAGLEY, SCOTT W.;CHAKRAVARTY, PRASUN K.;BROTEN, THEODORE P.;DHANOA, DALJIT S.;FITCH, KENNETH J.;KEVIN, NANCY J.;GREENLEE, WILLIAM J.;PETTIBONE, DOUGLAS J.;RIVERO, RALPH A.;WALSH, THOMAS F.;TATA, JAMES R.;WILLIAMS, DAVID L., JR. |
| 分类号 |
C07D295/14;A61K31/165;A61K31/19;A61K31/192;A61K31/215;A61K31/357;A61K31/36;A61K31/47;A61K31/535;A61K31/5375;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P13/02;A61P15/00;A61P29/00;A61P43/00;C07C59/68;C07C59/70;C07C65/24;C07C311/16;C07C311/51;C07D215/36;C07D257/04;C07D317/60;C07D317/64;C07D319/18;C07D405/12;C07D409/12;(IPC1-7):C07D317/46;C07D473/00;C07D413/12;A61K31/33 |
主分类号 |
C07D295/14 |
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