| 摘要 |
PURPOSE:To obtain a therapeutic agent for depression having high safety, comprising 1-(2,3-dimethylphenyl)piperazine having excellent antidepressive effect or its acid addition salt as active ingredients. CONSTITUTION:A new therapeutic agent for depression comprises 1-(2,3- dimethylphenyl)piperazine of the formula or its acid addition salt as an active ingredient and has an action mechanism different from that of a conventional therapeutic agent. Hydrobromic acid, sulfuric acid, acetic acid, citric acid, benzoic acid, aspartic acid, etc., may be cited as the acid of the acid addition salt. This therapeutic agent of depression is promising to prevent and improve depression, a depressive state and body symptoms followed by them or to alleviate progress of the disorder. The therapeutic agent for depression is useful as a therapeutic agent for serious depression, depressive feeling, bipolar disorder, anxiety disorder, expression disorder of body, dissociated disorder, sexual disorder, sleep disorder, falsification disorder, adjustment disorder, personality disorder and body symptoms caused by the diseases such as gastric ulcer, duodenal ulcer, ulcerative colitis and hypersensitive colitis. |
