| 摘要 |
<p>Decorin, a small collagen-binding dermatan sulfate proteoglycan, is widely distributed as a component of extracellular matrices. Decorin binds C1q at physiologic pH and ionic strength. Decorin core protein binds pepsin-derived fragments containing the collagenous domain of C1q and collagenase-derived fragments containing the globular domain of C1q. Decorin inhibits the hemolytic activity of purified C1 as well as C1 in normal human serum. Inhibition is not observed if C1 is bound to antigen-complexed antibody. Neither the core protein nor the glycosaminoglycan inhibits C1 indicating that the intact proteoglycan is necessary for functional activity. Therefore, decorin and related proteoglycans are useful in the suppression of complement activation of the immune system.</p> |
