| 摘要 |
The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the -CH2F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH2F is thus illustrated.
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