Synthesis of new disaccharides associating two derivatives of oses or of itols by means of a spacing arm, products obtained and applications, for example, as medication or surfactant

摘要

We have prepared new disaccharide compounds associating by glycoside linkage or otherwise, two derivatives of oses or of itols A and B in the form of diether between sites chosen in advance, by means of a divalent radical R, of formula I: <IMAGE> The process for the synthesis of these compounds includes especially the attack of a derivative of the unit A in alcoholate form on a reactant X-R1-X producing the intermediate A-R1-X which subsequently is subjected to attack of a derivative of the unit B in alcoholate form. The products obtained bear, respectively, 0 to 4 (n) groups ZIFI on the unit A and 0 to 4 (n') groups ZJGJ on the unit B, as well as a modulable number of free OH groups which may vary from 0 to 4 (p) on the unit A and from 0 to 4 (p') on the unit B. Surface-active and biological properties revealed by the products obtained are described with a view to applications as surface agents, catalysts for bleaching agents, calcium antagonist medications and antitumour medications.