摘要 |
<p>PURPOSE:To obtain a new compound having sufficiently high cell-adhesion protein-like activity, containing a peptide sequence having excellent cancer metastasis-suppressing action compared with the pore sequence of fibronectin, having high stability in blood and useful as a cancer metastasis suppressing agent. CONSTITUTION:The compound of formula I [R is peptide sequence of formula II (Arg is L- or D-arginine; Asp is L- or D-aspartic acid; X is L- or D-leucine or D-isoleucine; Z is none or Asp; Y is none or L-serine or L-threonine)] or its salt, e.g. the compound of formula III. This compound is produced by successively condensing protected amino acids by solid phase process or liquid phase process until the total protected peptide fragment is synthesized, removing the amino-terminal protecting group of the protected peptide, reacting the product with trimesoyl chloride in the presence of a dehydrohalogenation agent such as pyridine and deprotecting the reactional product.</p> |