| 摘要 |
PCT No. PCT/FR91/00927 Sec. 371 Date Jul. 16, 1993 Sec. 102(e) Date Jul. 16, 1993 PCT Filed Nov. 22, 1991 PCT Pub. No. WO92/09269 PCT Pub. Date Jun. 11, 1992.Formulations of spiramycin granules may be conducted by preparing a solution of albumin in the presence of an antifoaming agent, separately preparing a suspension of spiramycin in the presence of an antifoaming agent, granulating and drying a mixture of one or more sugars and water, mixing the albumin solution and spiramycin suspension with heating to coagulate the albumin, evaporating the solvents to obtain spiramycin granules, and mixing the sugar granules and spiramycin granules. Oral spiramycin formulations prepared according to this method are also disclosed. |
