| 发明名称 |
Carboxy terminal IL-6 muteins |
| 摘要 |
This invention relates to a Carboxy Terminal IL-6 Mutein with enhanced biological activity. The invention comprises a mutein of IL-6 having increased activity wherein the mutein has an amino acid substitution at, or corresponding to, amino acid location 171 or 175 of IL-6 having the wild-type sequence.
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| 申请公布号 |
US5338833(A) |
申请公布日期 |
1994.08.16 |
| 申请号 |
US19920918181 |
申请日期 |
1992.07.23 |
| 申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
FOWLKES, DANA M. |
| 分类号 |
C12N15/09;A61K38/00;C07H21/04;C07K14/52;C07K14/54;C07K19/00;C12N15/24;C12N15/62;C12P21/02;C12R1/19;(IPC1-7):C07K13/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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