GENE CODING MAGAKARYOCYTE AMPLIFIER

摘要

PURPOSE:To obtain a new DNA useful for the production of a megakaryocyte amplifier known as an agent for the treatment of diseases relating to the thrombocytopenia or platelet hypoactivity. CONSTITUTION:A DNA containing a base sequence coding the amino acid sequence of formula, a base sequence obtained by partly substituting or depleting the above base sequence or adding a fragment to the sequence or a base sequence hybridizing to the above sequence. It can be produced by preparing an mRNA from a cell capable of producing megakaryocyte amplifier, e.g. established cell HPC-Y5 (FERM BP-3703) originated from human pancreatic carcinoma cell and converting the mRNA to double stranded cDNA by conventional method.