| 摘要 |
Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them. The subject of the invention is the compounds of formula I <IMG> (I) in which Ar1 represents naphtyl, phenyl, quinolyl or isoquinolyl optionally substituted; Ar2 represents a phenyl or thienyl optionally substituted; R1, R2 and R'2 are independently of each other, H or (C1-C4)-alkyl; R1 represents nothing and N is attached to Ar2, and optionally R2 and R'2 form a double bond; or R1 or R2 is attached to Ar2 and represents a (C1C3 ) alkylene; R3 and R4, which are identical or different, represent H, (C1-C4)alkyl or form, with the nitrogen atom to which they are attached, a (C5-C7) saturated heterocycle selected from pyrrolidine, piperidine and hexahydroazepine; Z1 represents a (C1-C12)alkylene, optionally interrupted or extended by a (C5-C7)cycloalkyl or phenyl; Q1 represents methyl, amino, alkoxycarbonylamino, alkylamino, dialkylamino, a (C5-C7 ) saturated heterocyclic amino group, amidino, alkylamidino, guanidino, alkylguanidino, pyridyl, imidazolyl, pyrimidinyl, indolyl, hydroxy, alkoxy, (C2-C8)alkoxycarbonyl, amino(C1-C4)alkyl-N- (C1-C4) alkylamino or carbamoyl, or phenyl optionally substituted; Q2 represents H or alkyl; Q3 represents H or (C1-C4)alkyl; or Q1 and Q3 are attached to form a heterocycle and together represent a (C2) or (C3) alkylene, whereas Z1 represents nothing, in the form of pure enantiomers or mixtures thereof in any proportions, as well as their salts with acids. These compounds have an affinity for the biological receptors of neuropeptides Y (NPY), which are present in the central and peripheral nervous system. Fig. None
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