| 摘要 |
<p>Compounds of formula (I), or a salt, solvate or hydrate thereof, wherein Z represents a divalent group selected from those of formulae I(a) to I(g) defined in the specification; Y represents a single bond or a divalent group selected from those of formulae I(h) to I(j) defined in the specification; each Z independently represents hydrogen or a hydroxyl protecting group; R1 represents hydrogen or a group -CH(OZ)CH¿2?(OZ) wherein Z has the meaning defined above; R?2¿ represents hydrogen, a pharmaceutically acceptable cation, C¿1-6? alkyl, C2-6 alkenyl, or (optionally substituted)phenyl-(C1-4) alkyl; and R?3¿ represents hydrogen, C¿1-6? alkyl, (C1-4) alkyl-substituted phenyl or benzoate; and n is 1, 2 or 3. The compounds are ligands of E-, P-, and L-selectins and are useful as anti-inflammatory agents and as agents for the control of tumour metastasis.</p> |
