| 摘要 |
A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression of cyclins, particularly of cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. Altered expression of cyclins, such as overproduction of cyclins, particularly cyclin E, or production of alternative cyclin E proteins, as well as deranged appearance of mitotic cyclins during the cell cycle, are indicative of the presence of carcinoma, Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma.
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