Apparatus for peptide synthesis.

摘要

An apparatus for peptide synthesis of the present invention has a means of repeating a series of treatments consisting of washing, coupling, washing and deprotecting in a stream of an inert gas; a needle for injection /aspiration of reagents; and a microtiter plate with wells of which inner wall has a linker or a microtiter plate having a membrane filter, which has a linker, placed in its wells. The peptide synthesizer allows easy washing of the solid support with only a small amount of solvent. It also makes it possible to get the synthesized product as a peptide (or DNA) solution directly from the reaction vessel by sequentially performing cleavage in the reaction vessel (in situ cleavage) after the completion of peptide chain-assembly.