| 摘要 |
PURPOSE: To provide a halo-aromatic composition for diagnosis which can be prepared in a good yield. CONSTITUTION: This composition contg. radioactive iodine consists of a pharmaceutically-acceptable liquid blend and at least one adjuvant. The composition is produced by a method of producing a chloro-, bromo-, radioactive-bromo-, iodo- and/or radioactive-iodo-aromatic compound or if necessary, a (hetero) aromatic compound contg. at least one additional substituent, by reacting a halogenated or diazonium-substituted compound corresponding to the above compound, and a water-soluble chloride, bromide, radioactive bromide, indide or radioactive iodide, in the presence of a water-soluble acid or copper ions as a catalyst. At this time, this reaction is performed in the presence of at least one reducing agent which is stable in an acidic medium and the amount of which exceeds that of the catalyst. |
