发明名称 |
BIOERODIBLE CONTROLLED DELIVERY SYSTEM |
摘要 |
A controlled release medicament delivery system comprises a plasticized or unplasticized bioerodible polymer, such as a polyorthoester, suspended as a discontinuous phase in a hydrophobic liquid such as silicone oil or mineral oil as a continuous phase. Medicament desirably is entrapped at least partly by the discontinuous phase. The resulting delivery system is able to release the medicament in a controlled and sustainded manner. The formulation is particularly advantageous for use as a once-a-day eyedrop. During preparation, the polymer may be heated to an elevated temperature for a sufficient time to substantially reduce its molecular weight. Medicament may be added at a temperature above which there is complete phase separation.
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申请公布号 |
CA2153063(A1) |
申请公布日期 |
1994.07.07 |
申请号 |
CA19932153063 |
申请日期 |
1993.12.15 |
申请人 |
INSITE VISION INCORPORATED |
发明人 |
BOWMAN, LYLE M.;CHANDRASEKARAN, SANTOSH KUMAR;PATEL, RAJESH;VO, HOA VINH |
分类号 |
A61K9/107;A61K9/00;A61K47/34;(IPC1-7):A61K9/08;A61K9/06 |
主分类号 |
A61K9/107 |
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