发明名称 |
Heterocyclic compounds having angiotensin II antagonistic activity and use thereof. |
摘要 |
<p>This invention relates to a compound represented by the formula <CHEM> wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R<1> and R<2>, further substituents; R<1> stands for an optionally substituted hydrocarbon residue which is optionally bonded through a hetero-atom; R<2> stands for a group capable of liberating proton in a living body or a group convertible thereinto; R<3> stands for an 5-7 membered optionally substituted heterocyclic residue having, as a group capable of constituting the ring, carbonyl group, thiocarbonyl group, an optionally oxidized sulfur atom or a group convertible into them; X shows that the ring Y and the ring W are bonded to each other directly or through a spacer having an atomic length of two or less; the ring W and the ring Y are each an optionally substituted aromatic hydrocarbon or aromatic heterocyclic residue; and n denotes an integer of 1 to 3, or a salt thereof and to an angiotensin II antagonistic agent containing the compound (I) or a salt thereof.</p> |
申请公布号 |
EP0603712(A2) |
申请公布日期 |
1994.06.29 |
申请号 |
EP19930120135 |
申请日期 |
1993.12.14 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
KUBO, KEIJI;INADA, YOSHIYUKI;NAKA, TAKEHIKO |
分类号 |
C07D413/10;C07D417/10;(IPC1-7):C07D413/10;A61K31/41 |
主分类号 |
C07D413/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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