| 摘要 |
The invention relates to phenylacetic acid derivatives, a process for the preparation thereof and corresponding use. These derivatives are identified by the following formula: <IMG> where R1, R2 and R3 are the same or different and are a either methyl, ethyl or propyl radicals; or R2 and R3, which are attached as shown by -(R2....R3)-, jointly form a -(CH2)n- radical where n = 4 or 5, with the exception of the case where R1 = R2 = R3 = CH3, and also with the exception of the case where R1 = R3 = CH3 and R2 = ethyl; the process comprises the reaction of a diclofenac salt with the corresponding alkyl haloacetate of formula X-CH2-COO-CR1R2R3, (X = Cl or Br) in an homogenous medium. They are used for the preparation of ¢2-(2,6-dichloroanilino)phenyl!acetoxyacetic acid, by treatment with acids in an anhydrous medium. The derivatives have therapeutic activity as analgesics or anti-inflammatories.
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