PROCESS OF CONJUGATION OF ANTIVIRAL NUCLEOSIDES WITH LACTOSAMINATED HUMAN ALBUMIN

摘要

By carrying out the conjugation reaction of an antiviral phosphorylated nucleoside, particularly arabinoside adenine monophosphate, in form of an imidazolide, with lactosaminated human albumin at a pH higher than 7.5, molar ratios drug/L-HSA at least equal to those using ECDI without the problems and negative side effect observed in these latter are obtained. Preferably, the conjugation reaction is carried out at a temperature of 37 DEG C and a pH of 8.5-9.5.