METHOD FOR THE PREPARATION OF 1,3-OXAZOLIDIN 5-CARBOXYLIC ACID

摘要

Method for the preparation of 1,3-oxazolidin 5-carboxylic acid having the general formula (I) from a product having the general formula (II). In the general forumlas (I) and (II), Ar is an aryl radical, R1 is a benzoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, Ph is an optionnally substituted phenyl radical, X is the residue of an optically active organic base or an alkoxy radical optionally substitued by a phenyl radical. The acids of formula (I) are particularly useful in preparing taxol, Taxoter or analogs thereof which have remarkable antitumor and antileukemia properties.