PROTECTIVE ROLE OF POLYAMINES IN MODIFICATIONS OF BASEMENT MEMBRANE MACROMOLECULES
摘要
Polyamines including putrescine are found to interfere with nonenzymatic glucosylation, interfere with formation of advanced glucosylation end-products by minimizing crosslink formation and act as a reducing agent to minimize oxidative damage to proteins. These polyamines are useful in treating diabetics to minimize damage caused by the high glucose concentrations and to reduce cross-linking-mediated or oxidation-mediated tissue aging.
申请公布号
WO9412464(A1)
申请公布日期
1994.06.09
申请号
WO1993US11769
申请日期
1993.12.03
申请人
CHARONIS, ARISTIDIS, S.;FURCHT, LEO, T.;CANELLAKIS, EVANGELO;TSILIBARY, PHOTINI-EFFIE, C.;ZIOUDROU, CHRISTINA
发明人
CHARONIS, ARISTIDIS, S.;FURCHT, LEO, T.;CANELLAKIS, EVANGELO;TSILIBARY, PHOTINI-EFFIE, C.;ZIOUDROU, CHRISTINA