Substituted derivatives of diaminophthalimide as protein-tyrosine kinase inhibitors.

摘要

There are described compounds of the formula I in which A1 and A2 independently of one another denote substituted lower alkyl, substituted lower alkenyl, substituted lower alkynyl or hydrogen, it being possible for at most one of the radicals A1 and A2 to denote hydrogen, or A1 and A2 together denote lower alkylene substituted by substituents other than lower alkyl and other than hydroxyl; Ar1 and Ar2 independently of one another denote aryl, heteroaryl or unsubstituted or substituted cycloalkyl, the group -C(=X)- stands for -C(=O)-, -C(=S)-, -CH2- or -C(-CR1R2)-, where R1 and R2 independently of one another denote hydrogen or lower alkyl, and R denotes hydrogen, lower alkyl, aryl-lower alkyl, aryl, amino, hydroxyl or lower alkoxy, salts thereof if salt-forming groups are present, and/or tautomers thereof if tautomerisable radicals are present, process for the preparation of these compounds, pharmaceutical preparations which contain these compounds, and the use of these compounds for the therapeutic treatment of the human or animal body or for the production of pharmaceutical preparations.