发明名称 |
Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
摘要 |
PCT No. PCT/US90/03367 Sec. 371 Date Dec. 12, 1991 Sec. 102(e) Date Dec. 12, 1991 PCT Filed Jun. 13, 1990.A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead atom wherein said second ring may also contain sulfur, oxygen or an additional nitrogen atom, and may contain additional unsaturation. This invention relates to a method of inhibiting the production of Tumor Necrosis Factor (TNF) by monocytes or macrophages in a human in need thereof which comprises administering to such mammal an effective, TNF production inhibiting amount of a compound of Formula (I) as described herein. The compounds of Formula (II) are generally described as diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead wherein said ring may also contain sulfur, oxygen, or an additional nitrogen atom, and may contain additional unsaturation.
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申请公布号 |
US5317019(A) |
申请公布日期 |
1994.05.31 |
申请号 |
US19910809484 |
申请日期 |
1991.12.12 |
申请人 |
SMITHKLINE BEECHAM CORP. |
发明人 |
BENDER, PAUL E.;GRISWOLD, DON E.;HANNA, NABIL;LEE, JOHN C.;VOTTA, BARTHOLOMEW J.;SIMON, PHILIP L.;BADGER, ALISON M.;ESSER, KLAUS M. |
分类号 |
A61K31/42;A61K31/425;A61K31/435;A61K31/44;A61K31/54;A61K31/55;A61P29/00;A61P43/00;C07D471/04;C07D487/04;C07D498/04;C07D513/04;(IPC1-7):A01N43/40 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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