ANTISENSE OLIGONUCLEOTIDES TO INHIBIT EXPRESSION OF MUTATED AND WILD TYPE GENES FOR COLLAGEN

摘要

The invention is an oligonucleotide substantially complementary to a mutant collagen nucleotide sequence and not perfectly complementary to a wild type collagen nucleotide sequence, methods for selecting and preparing such an oligonucleotide, and methods for treating mammals having diseases exhibiting mutant collagen gene expression using such an oligonucleotide to inhibit mutant collagen gene expression.