摘要 |
Compounds and pharmaceutical compositions thereof comprise the formula: (R)j - ( core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof , wherein j is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring str ucture, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted benzyl, alky l (C1-6) or alkenyl (C1-6), and at least one R has formula (I), wherein n is an integer from four to eighteen; each R'1 and R'2 is independently hydrogen, alkyl (C1-4) or alkenyl (C1-4), the alkyl or alkenyl groups being preferably substituted by a ha logen, hydroxyl, ketone or dimethylamino group and/or may be interrupted by an oxygen or hydrogen atom or an alkyl (C1-4) group; and each R'3 and R'4 is independently hydrogen or methyl. Preferably, n is an integer from six to ten, R'1 and R'2 are independently hydrogen or methyl and R'3 and R'4 are hydrogen. The compounds are useful in treating or preventing , for example, sepsis syndrome, hematopoietic or organ toxicity, baldness, hair loss or allopecia caused by cytotoxic therapie s, and progression of an inflammatory or autoimmune disease.
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