发明名称 |
TARGETABLE VECTOR PARTICLES |
摘要 |
2148934 9411524 PCTABS00032 A vector particle (e.g., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is other than the amphotropic cell receptor. The receptor binding region may be a receptor binding region of a human virus. A portion of the envelope gene may be deleted and the deleted portion is replaced with another receptor binding region or ligand. Such vector particles are targetable to a desired target cell or tissue, and may be administered directly to the desired target cell or tissue as part of a gene therapy procedure, or administered directly into the patient.
|
申请公布号 |
CA2148934(A1) |
申请公布日期 |
1994.05.26 |
申请号 |
CA19932148934 |
申请日期 |
1993.11.03 |
申请人 |
UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF THE HEALTH AND HUMAN SERVICES (THE) |
发明人 |
ANDERSON, FRENCH W.;BALTRUCKI, LEON F.;MASON, JAMES M. |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C07K14/15;C07K14/47;C12N5/10;C12N15/58;C12N15/867;C12N15/87;(IPC1-7):C12N15/86;C12N7/01;C12N15/12;C12N15/48;C12N15/51 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|