AVIRULENT LIVE VACCINE AND METHOD FOR IMMUNIZING ANIMALS AGAINST P. MULTOCIDA PASTEURELLOSIS

摘要

2148829 9411024 PCTABScor01 The invention provides vaccines and methods for protecting an animal against P. multocida associated pasteurellosis. A vaccine of the invention can be comprised of a stable avirulent immunogenic P. multocida mutant or a recombinantly produced P. multocida) virulence factor. The avirulent immunogenic mutant can be a transposon-mediated mutant or a mutant having at least one genetically modified virulence gene. The methods of the invention include steps of producing an avirulent immunogenic mutant and administering an effective amount of the mutant to protect an animal against P. multocida pasteurellosis.