| 摘要 |
PCT No. PCT/GB91/01456 Sec. 371 Date Feb. 23, 1993 Sec. 102(e) Date Feb. 23, 1993 PCT Filed Aug. 29, 1991 PCT Pub. No. WO92/04323 PCT Pub. Date Mar. 19, 1992.Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 represents a 1,2,5,6-tetrahydropyridin-3-yl group N-substituted by R10 wherein R10 represents hydrogen, C1-2 alkyl, prop-2-enyl, prop-2-ynyl or cyclopropyl, R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, a group OCOR5 where R5 is hydrogen or R4, or a group NHR6, or NR7R8 where R6, R7 and R8 are independently C1-2 alkyl; and R3 is chloro, fluoro, bromo, methoxy, C1-3 alkyl substituted by one, two or three halogen atoms, or R3 is a group (CH2)nR9 where R9 is -CN, -SH or -SCH3 and n is 0 or 1, with the proviso that when n is 0, R9 is not -SH; enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals. <IMAGE> (I)
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