OPTISCH AKTIVE AZETIDINONE UND VERFAHREN ZU DEREN HERSTELLUNG.

摘要

PCT No. PCT/JP87/00991 Sec. 371 Date Aug. 18, 1988 Sec. 102(e) Date Aug. 18, 1988 PCT Filed Dec. 18, 1987 PCT Pub. No. WO88/04656 PCT Pub. Date Jun. 30, 1988.This invention provides compounds of the formula (I) wherein Y represents an acetyl, 1-hydroxyethyl or 1-fluoroethyl group, R1 represents a hydrogen atom or an easily splittable amino-protecting group, and R2 and R3 are identical or different and each represents a hydrogen atom, a lower alkyl group, a phenyl group, a benzyl group or a diphenylmethyl group, or R2 and R3 together represent a lower alkylene group; and processes for production thereof. These compounds are useful as synthesis intermediates for production of various medicines, particulary carbapenam or carbapenem antibiotics, such as a carbapenem antibiotic of the following formula which has excellent antimicrobial activity and relatively good stability to kidney dehydropeptidase. (A)