发明名称 |
METHOD OF INHIBITING REPLICATION OF HYPERPROLIFERATIVE CELLS |
摘要 |
This invention relates to methods for converting a pathologic hyperproliferative human cell to its non-malignant phenotype. The method comprises introducing into the cell a nucleic acid encoding a polypeptide having adenovirus E1A activity and growing the cellunder conditions such that the polypeptide is produced. This invention also relates to a method of converting a population of pathologic hyperproliferative cells in a subject to a non-hyperproliferative state by expressing, in some but not all of the hyperproliferative cells, an isolated nucleic acid sequence encoding a polypeptide having adenovirus E1A activity. In a further aspect, the invention relates to promoting differentiation of pathologically hyperproliferative cells. |
申请公布号 |
WO9409160(A1) |
申请公布日期 |
1994.04.28 |
申请号 |
WO1993US09774 |
申请日期 |
1993.10.13 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
FRISCH, STEVEN, M. |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P35/00;C07H21/04;C07K14/075;C07K14/82;C12N5/10;C12Q1/68;(IPC1-7):C12Q1/68;C12N15/00;C12N5/00;C12P21/06;C12Q1/70;A01N43/04;C07H21/00;C07H19/00;C07H17/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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