PLASTER FOR THE TRANSDERMAL ADMINISTRATION OF VOLATILE, PHARMACEUTICALLY ACTIVE, CHEMICALLY ALKALINE INGREDIENTS, AND PROCESSS FOR PRODUCING THE SAME

摘要

A plaster for the transdermal administration of volatile, pharmaceutically effective, chemically alkaline ingredient has a multiple element system comprising: (a) a matrix in which the above-mentioned volatile substance or one of its physiologically acceptable salts is distributed as active substance, the matrix containing an adhesive, (b) an element of an adhesive composition which, when (a) contains a salt, contains alkaline groups which release the free base from their salt, (c) a backing layer impervious to the diffusable ingredients mentioned under (a) and (b), and (d) a pulling-off foil impervious to the diffusable ingredients mentioned under (a) and (b). The matrix (a) or at least part of (b), depending whether the matrix or the part of (b) is in contact with the pulling-off foil (d), has a stickiness (tack) sufficient for securing the plaster on the skin. Each part of (b) arranged between matrix (a) and pulling-off foil (d) is pervious to the active substance, preferably deprenyl and/or one of its salts. A process for producing such a plaster is also dislcosed.