Antiparasitic compounds of formula (I): <CHEM> The broken line at the 22-23 position representing an optional double bond and either R<1> is H or OH and the double bond is absent or the double bond is present and R<1> is absent; R<2> is optionally substituted phenyl, or a group of formula (II): <CHEM> wherein X is 0, S or -CH2-, abc and d are 0-2 and a+b+c+d</=5 R<3> is H or Me R<4> is H, OH or 4<1>-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy. The compounds are prepared by fermentation of Streptomyces avermitilis in the presence of an N-alkanoyl cysteamine thioester containing R<2>.
申请公布号
DE68912007(T2)
申请公布日期
1994.04.28
申请号
DE1989612007T
申请日期
1989.06.26
申请人
PFIZER, INC., NEW YORK, N.Y., US
发明人
DUTTON, CHRISTOPHER JAMES, DR., SANDWICH KENT, GB;WALSHE, NIGEL DEREK ARTHUR, DR., DEAL KENT, GB;GIBSON, STEPHEN PAUL, DR., MARGATE KENT, GB