| 摘要 |
PCT No. PCT/JP90/01625 Sec. 371 Date Apr. 22, 1991 Sec. 102(e) Date Apr. 22, 1991 PCT Filed Dec. 12, 1990 PCT Pub. No. WO91/08736 PCT Pub. Date Jun. 27, 1991.By forming a multi-layer preparation comprising a tablet or granule containing a medicine as the core and the outermost layer comprising a plasma-decomposable polymer and a plasma-crosslinkable polymer and irradiating the outermost layer with a plasma about release-regulating preparations according to the plasma irradiation, the direct exposure of the medicine to the plasma can be avoided and the release pattern can be controlled more easily.
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