发明名称 |
HERSTELLUNG VON GLYCIDYLÄTHER. |
摘要 |
This invention relates to a method for producing a glycidyl ether of general formula (I), wherein A is an optionally substituted aryl or heteroaryl group and the asterisked carbon atom represents an asymmetric carbon atom, comprising reacting an aryl alcohol of the general formula A-OH, wherein A is as defined above, with an epihalohydrin in the presence of a quaternary ammonium salt and, if necessary, treating the reaction product with a base. This method can afford the glycidyl ether of formula (I), which is useful as an intermediate of drugs, especially a beta -blocker, in a simplified manner with a high optical purity. |
申请公布号 |
DE68913965(D1) |
申请公布日期 |
1994.04.21 |
申请号 |
DE1989613965 |
申请日期 |
1989.12.25 |
申请人 |
KOWA CO., LTD., NAGOYA, AICHI, JP |
发明人 |
KAWAMURA, KIYOSHI, SAITAMA 352, JP;OTA, TOMIO, SAITAMA 350-13, JP |
分类号 |
C07D301/28;C07D303/22;C07D405/12;C07D407/12;C07D417/12 |
主分类号 |
C07D301/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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