25-CARBOXYLIC ACID DERIVATIVES IN THE VITAMIN D SERIES, METHOD OF PRODUCING THEM, INTERMEDIATE PRODUCTS FOR THIS METHOD, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN THE MANUFACTURE OF MEDICINES

摘要

Described are the new 25-carboxylic acid derivatives of general formula (I), R19 and R19a each denoting a hydrogen atom or in common an exocyclic methyl group, R21 and R21a independently of each other denoting a hydrogen atom, a chlorine or fluoride atom, an alkyl group with 1-4 carbon atoms, in common a methylene group, a 3-7 membered, saturated or unsaturated carbocyclic ring in common with the quaternary 20 carbon atom, Y preferably denoting a derivatized carboxyl residue, with the other substituents as indicated in the description, and a method of producing them. The new compounds posses vitamin D activity as well as antiproliferative and cell-differentiating action and can be used in the manufacture of medicines.