| 摘要 |
PURPOSE:To obtain a new cyclopentenone compound having improving action on strong anoxia and cerebral ischemia, having low toxicity and exhibiting effects also on every one of oral and parenteral administrations and exhibiting cerebral function-improving action. CONSTITUTION:A cyclopenteone compound of formula I [R1 is H, Br, Cl or di-substituted aminomethyl; R2 is substituted phenyl to which 1-2 F, Cl or nitro are bound or phenylmethyl of formula II (R3 is H, phenyl or pyridyl; R4 is H, F, Cl or dimethylamino), e.g. 3-(2,3-dichloroanilino)-2-cyclopentene-1-one. The compound of formula I is obtained by reacting 1,3-cyclopentanedione of formula III with amines of formula IV. |
