RESOLUTION OF KETOPROFEN

摘要

A method for resolving (+/-)-/ alpha /-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; ii) separating the diastereomeric salt from such conversion; iii) purifying said separated diastereomeric salt by a single recrystallization; and iv) isolating highly pure (+)- alpha -(3-benzoylphenyl)propionic acid without any further recrystallization.