发明名称 |
Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes |
摘要 |
A formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes comprising animal serum, creatine kinase and/or creatine kinase isoenzymes, an effective amount of a buffer having a pKa in the range of 6.2-7.6 to maintain pH of the formulation at 6.7+-0.1, an effective amount of a non-thiol antioxidant to prevent oxidation of creatine kinase or creatine kinase isoenzyme thiol groups, an effective amount of a non-reducing polyol to stabilize immunoreactivity of creatine kinase or creatine kinase isoenzymes, and an effective amount of an antimicrobial to prevent microbial growth is provided.
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申请公布号 |
US5298406(A) |
申请公布日期 |
1994.03.29 |
申请号 |
US19920939861 |
申请日期 |
1992.09.14 |
申请人 |
E. I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
LOYD, JOSEPH E.;SEARCH, BARBARA A. |
分类号 |
C12N9/12;C12N9/96;C12Q1/50;G01N33/573;(IPC1-7):C12Q1/50 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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