| 摘要 |
<p>PURPOSE:To obtain a new compound, having antidement, antiischemic and antidepressant actions and useful as an antidepressant agent and a therapeutic agent for sequelae of cerebral angiopathy. CONSTITUTION:The piperidine derivative of formula I (X<1> and X<2> are lower alkyl, lower alkoxy or halogen), e.g. 1-[3-{4-(3,4-dichlorophenyl)piperidin-1- yl}propylcarbamoyl]-2-oxopyrrolidine. This compound of formula I is obtained by reducing a compound of formula II (R is amino-protecting group), etc., providing a compound of formula III and then reacting the resultant compound of formula III with 1-{3-(chloropropyl)carbamoyl}-2-oxopyrrolidine.</p> |
