CEREBRAL HYPERKINEMIC COMPOSITION CONTAINING A DIHYDROPYRIDINE DERIVATIVE

摘要

A cerebral hyperkinemic composition which containa as an effective ingredient at least a dihydropyridine derivative of the general formula <IMG> wherein R1, R2 and R3, which are identical or different, independently represent an alkyl, a cycloalkyl or an alkoxyalkyl; R4 and R5, which are identical or different, independently represent a hydrogen atom, a halogen, nitro, a halogenated alkyl, an alkylsulfonyl, a halogenated alkoxy, an alkylsulfinyl, an alkyl, a cycloalkyl, an alkoxy, cyano, an alkoxycarbonyl or an alkylthio, both R4 and R5 not being a hydrogen atom; X represents vinylene or azomethine group; A represents an alkylene; and Ar represents a phenyl, which may be substituted, or an acid addition salt thereof in an effective amount. The dihydropyridine derivatives (I) and their acid addition salts have extremely low toxicity and potent and lasting cerebral vasodilative actions in mammals, and thus are useful as cerebral vasodilators and agents for the prophylaxis and therapy of cerebral circulation disorders.