| 摘要 |
The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. The PUR proteins bind specifically to single stranded DNA in regions that coincide with eukaryotic origin of replication, one of such is at the c-myc gene region shown in the figure; this indicates that PUR proteins may function to regulate DNA replication. Inhibitors of PUR activity may be used to treat hyperproliferative diseases such as cancer.
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