发明名称 |
ROKITAMYCIN MONOHYDRATE CRYSTAL AND PROCESS FOR PRODUCING THE SAME |
摘要 |
A rokitamycin monohydrate crystal (hereinafter referred to as "RKM hydrate") represented by formula (1), and a process for producing RKM hydrate by crystallizing rokitamycin from the acidic aqueous solution thereof. The novel RKM hydrate is so extremely improved in bitterness over rokitamycin itself that it is unnecessary to hide the bitterness of the rokitamycin heretofore used and it is possible to prepare medicated syrups with the qualities superior to those of the conventional ones in a simpler process from RKM hydrate. Further, RKM hydrate is so excellent in wettability with water that it is possible to prepare tablets with the qualities equivalent to those of the conventional ones without the necessity for conducting the conventional surface treatment with a sucrose/fatty acid ester. |
申请公布号 |
WO9405683(A1) |
申请公布日期 |
1994.03.17 |
申请号 |
WO1993JP01189 |
申请日期 |
1993.08.25 |
申请人 |
ASAHI KASEI KOGYO KABUSHIKI KAISHA |
发明人 |
KINOSHITA, KENJI |
分类号 |
A61K31/70;A61K31/7042;A61K31/7048;A61P31/04;C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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