发明名称 |
PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN |
摘要 |
A filamentous phage is described comprising a matrix that includes a heterologous polypeptide fused to a first filamentous phage coat protein membrane anchor and a heterodimeric receptor comprised of first and second receptor polypeptides, wherein one of the receptor polypeptides is fused to a second filamentous phage coat protein membrane anchor. Filamentous phage expressing anchored heterodimeric receptors and dimers of heterologous polypeptides where a first subunit of the dimer is fused to a coat protein membrane anchor and the second subunit of the dimer is soluble heteromeric receptor are also described. |
申请公布号 |
WO9405781(A1) |
申请公布日期 |
1994.03.17 |
申请号 |
WO1993US08364 |
申请日期 |
1993.09.03 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
LIGHT, JAMES, PAUL, II;LERNER, RICHARD, A. |
分类号 |
G01N33/53;C07K14/705;C07K16/00;C07K16/44;C12N1/21;C12N7/01;C12N15/09;C12N15/10;C12P21/02;C12Q1/02;C12Q1/70;C12R1/92;C40B40/02;G01N33/569;(IPC1-7):C12N15/00;C12Q1/00;C12P21/06 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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