发明名称 IMMUNOSUPPRESSIVE SUBSTANCE AND METHOD FOR FRACTIONATING THE SAME
摘要 PURPOSE:To find and isolate a new immunosuppressive substance from an animal except bovine and mouse in which a substance having immunological activity in salivary gland has been known to exist. CONSTITUTION:A immunosuppressive substance is obtained from submandibular gland of rabbit, is white powder, has 30-60kD(kiloDalton) molecular weight measured by disc electrophoresis of SDS-10% polyacrylamide and Sephadex G-100, pH4.5-6.5 isoelectric point, is soluble in water and sodium chloride injection, insoluble acetone, is wholly positive to ninhydrin reaction, biuret reaction, Millon reaction, Sakaguchi reaction, Molish reaction, anthrone reaction and Erson-Morgan reaction and has a partition coefficient of about 0.25-0.75.
申请公布号 JPH0665296(A) 申请公布日期 1994.03.08
申请号 JP19920220284 申请日期 1992.08.19
申请人 TEIKOKU HORMONE MFG CO LTD 发明人 KOBAYASHI MASAO;ISHIZAKA SHIGEAKI;FURUSAWA YOSHIO;TAMAKI KENJI
分类号 A61K35/55;A61K38/00;A61P37/00;A61P37/04;C07K1/14;C07K14/435 主分类号 A61K35/55
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