摘要 |
PURPOSE:To find and isolate a new immunosuppressive substance from an animal except bovine and mouse in which a substance having immunological activity in salivary gland has been known to exist. CONSTITUTION:A immunosuppressive substance is obtained from submandibular gland of rabbit, is white powder, has 30-60kD(kiloDalton) molecular weight measured by disc electrophoresis of SDS-10% polyacrylamide and Sephadex G-100, pH4.5-6.5 isoelectric point, is soluble in water and sodium chloride injection, insoluble acetone, is wholly positive to ninhydrin reaction, biuret reaction, Millon reaction, Sakaguchi reaction, Molish reaction, anthrone reaction and Erson-Morgan reaction and has a partition coefficient of about 0.25-0.75. |