A reliable flow rate plasmapheresis system includes a rotating enhanced vortex of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in response thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starting anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.
申请公布号
DE3689533(D1)
申请公布日期
1994.02.24
申请号
DE19863689533
申请日期
1986.03.21
申请人
MCLAUGHLIN, WILLIAM FRANCIS, NEWPORT BEACH, CALIF., US
发明人
SCHOENDORFER, DONALD, WALTER, SANTA ANA, CA 92705, US;WILLIAMSON, LEE H., EL TORO CALIFORNIA 92630, US