发明名称 |
Preparation process of alpha-aspartyl-L-phenylalanine methyl ester |
摘要 |
alpha -L-Aspartyl-L-phenylalanine methyl ester ( alpha -APM) is prepared by catalytic hydrogenation of N-benzyloxycarbonyl- alpha -L-aspartyl-L-phenylalanine methyl ester (Z- alpha -APM). The catalytic hydrogenation is conducted in an aqueous suspension containing the Z- alpha -APM in the form of particles whose average particle size is not greater than 800 mu m. The starting Z- alpha -APM may contain up to 30 wt.% of its beta -isomer provided that the process additionally includes recrystallization of the alpha -APM, collection of the alpha -APM by filtration and recycling of the filtrate for use in the aqueous suspension of Z- alpha -APM. |
申请公布号 |
AU646556(B2) |
申请公布日期 |
1994.02.24 |
申请号 |
AU19920015101 |
申请日期 |
1992.04.23 |
申请人 |
MITSUI TOATSU CHEMICALS INCORPORATED |
发明人 |
CHOJIRO HIGUCHI;IKUMI KITADA;AKINORI NAGATOMO;KATASHI ENOMOTO;MASANOBU AJIOKA;AKIHIRO YAMAGUCHI |
分类号 |
A23L27/30;C07K5/075 |
主分类号 |
A23L27/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|