BIOLOGICAL APPLICATIONS OF ALKALOIDS DERIVED FROM THE TUNICATE EUDISTOMA sp.

摘要

Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp., as well as the preparation of synthetic pyridoacridines, and particularly methods for the synthesis of Eilatin are disclosed. A method regulating cell growth includes contacting one or more cells with an effective concentration of compound for regulating cell growth. These compounds include: Segoline A, Segoline B, Isosegoline A, Norosegoline, Debromoshermilamine, Eilatin, 4-methylpyrido[2,3,4-kl] acridine, pyrido[2,3,4-kl]acridine, 1-acetyl-2, 6-dimethylpyrido[2,3,4-kl]acridine, and derivatives and combinations of these compounds.